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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: MMP11 All Species: 28.18
Human Site: Y446 Identified Species: 68.89
UniProt: P24347 Number Species: 9
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P24347 NP_005931.2 488 54618 Y446 A F Q D A D G Y A Y F L R G R
Chimpanzee Pan troglodytes XP_515022 469 52600 Y427 A F Q D A D G Y A Y F L R G R
Rhesus Macaque Macaca mulatta XP_001083910 488 54748 Y446 A F Q D A D G Y A Y F L R G R
Dog Lupus familis XP_543534 489 54823 Y447 A F R D A D G Y A Y F L R G R
Cat Felis silvestris
Mouse Mus musculus Q02853 492 55423 Y450 A F Q D A E G Y A Y F L R G H
Rat Rattus norvegicus Q499S5 491 55493 Y449 A F Q D A E G Y A Y F L R G H
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_001232777 502 56708 F460 A F Q D E L G F A Y F L R G Q
Frog Xenopus laevis Q11005 477 54423 Y432 A F Q D E Q G Y A Y F V K G R
Zebra Danio Brachydanio rerio XP_692205 483 55535 F446 A F Q E A S G F V V F I S R R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_780356 489 56331 Y427 V F R H Y D G Y S W N T Y F I
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 93 97.3 86.9 N.A. 81.7 81.6 N.A. N.A. 64.3 61.4 56.3 N.A. N.A. N.A. N.A. 39.8
Protein Similarity: 100 93.4 97.7 91.4 N.A. 87.4 86.7 N.A. N.A. 73.9 73.9 67.4 N.A. N.A. N.A. N.A. 53.1
P-Site Identity: 100 100 100 93.3 N.A. 86.6 86.6 N.A. N.A. 73.3 73.3 46.6 N.A. N.A. N.A. N.A. 26.6
P-Site Similarity: 100 100 100 100 N.A. 93.3 93.3 N.A. N.A. 86.6 86.6 66.6 N.A. N.A. N.A. N.A. 46.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 90 0 0 0 70 0 0 0 80 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 80 0 50 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 0 10 20 20 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 100 0 0 0 0 0 20 0 0 90 0 0 10 0 % F
% Gly: 0 0 0 0 0 0 100 0 0 0 0 0 0 80 0 % G
% His: 0 0 0 10 0 0 0 0 0 0 0 0 0 0 20 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 10 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 10 0 0 % K
% Leu: 0 0 0 0 0 10 0 0 0 0 0 70 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 10 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 0 80 0 0 10 0 0 0 0 0 0 0 0 10 % Q
% Arg: 0 0 20 0 0 0 0 0 0 0 0 0 70 10 60 % R
% Ser: 0 0 0 0 0 10 0 0 10 0 0 0 10 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 10 0 0 0 % T
% Val: 10 0 0 0 0 0 0 0 10 10 0 10 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 10 0 0 0 0 0 % W
% Tyr: 0 0 0 0 10 0 0 80 0 80 0 0 10 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _